PGT-M

PGT-M

Right Embryo
A genetic test designed to reduce the risk of having
a child with an inherited condition

PGT-M

PGT-M icon

PGT-M

Right Embryo
A genetic test designed to reduce the risk of having
a child with an inherited condition

fast-track-pgtm

Fast-Track PGT-M Service: Empowering Families and Clinicians

Leveraging cutting-edge amplification technology to provide a new premium Fast-Track PGT-M service.

What to Expect 

PGTM-standardPrevious testing process
2-3 months

PGTM-CSINEW Fast-Track PGT-M
4 weeks*

Benefits of Fast-Track PGT-M service

Icons-tick Potentially improving patient experience

Icons-tickCould facilitate earlier IVF cycling (following case review and acceptance)

Icons-tickDesigned to streamline the PGT-M process for clinics and patients

A legacy of PGT innovation

CooperSurgical® boasts 30+ years of PGT-M experience, with over 10,000 procedures conducted.¹ Our technology carries on the tradition established by those pioneers who performed the first PGT-M cases,² and played an integral role in shaping our genomics organization.

Fast-Track PGT-M service

We’re excited to introduce a revolutionary amplification technology, unique to CooperSurgical, that will improve the patient experience while streamlining processes for the clinician.

* Effective form January 1st, 2024, all referred qualifying PGT-M cases will be subject to a 4-week turnaround that is initiated upon completion of case acceptance and receipt of required materials.

1. Internal CooperSurgical data
2. Handyside AH, Lesko JG, Tarín JJ, Winston RM, Hughes MR. Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis. New England Journal of Medicine. 1992 Sep 24;327(13):905-9.

Common disorders** covered by Fast-Track PGT-M service

Most frequent disorders
Please contact CooperSurgical to confirm whether specific disorders can be accepted

Cystic Fibrosis
Spinal muscular atrophy (variations)
Fragile X syndrome
Sickle cell anemia
Hereditary breast-ovarian cancer 1
Hereditary breast and ovarian cancer syndrome (BRCA1/2)
Huntington Disease

Myotonic dystrophy 1+2
Neurofibromatosis 1+2
21-hydroxylase deficient congenital adrenal hyperplasia
Hemophilia A
Familial adenomatous polyposis
Marfan syndrome
Autosomal dominant polycystic kidney disease (PKD1/2)

**These are examples of common conditions that may be available for the Fast-Track service, however, CooperSurgical reserves the right to review cases based upon technical factors related to the specific mutation.

Genomics-target-icon

High accuracy – Improved genome coverage leads to better confidence in our results.

Choose CooperSurgical® Genomics Testing

All our innovation requires a significant investment of our resources and time. At CooperSurgical we believe that this cost should not be passed onto the patient, so the innovations and improvements to PGT-M described here, will not increase the cost to you or your patients. Furthermore, you can rest assured that you will receive the same quality of services you’ve come to expect.

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Your Questions Answered

Q: Do I need to change any of my laboratory processes?
A: There are no required changes to your laboratory processes.

Q: Will there be an added cost for the Fast-Track PGT-M service?
A: No, there is no added cost for this service.

Q: Will there be any changes to the report?
A: No, there will not be any changes to the report format or delivery.

Q: When will I be able to benefit from this service?
A: Cases referred after January 1st, 2024, will benefit from this streamlined service.

For people who know they are at increased risk of passing on a specific genetic condition.

PGT-M, or preimplantation genetic testing for monogenic/single gene defects, can be performed prior to pregnancy to greatly reduce the risk of having an affected child.

PGT-M involves testing embryos created through in vitro fertilization (IVF) and then transferring unaffected embryos.

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In the last ten years we have performed over 15,000 PGT-M cases on >1,000 different disorders 1

Key Product Information

Reproductive Genetic Testing Brochure

PGT-M Patient Brochure

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Who is it for?

PGT-M is appropriate for people who are at high-risk of passing on a specific single gene disorder. You may consider PGT-M if:

  • You and your partner are carriers of the same autosomal recessive condition (e.g. Cystic fibrosis)
  • You are a carrier of an X-linked condition (e.g. Duchenne Muscular Dystrophy)
  • You or your partner have an autosomal dominant condition (e.g. Huntington disease)
  • You or your partner have a mutation associated with a hereditary cancer syndrome (e.g. BRCA1 & 2)
  • You had a child or pregnancy with a single gene disorder
  • You want to perform HLA matching

PGT-M Technology

PGT-M testing involves a close examination of both the mutation an individual carries and the area of the chromosome surrounding it, shown above as the colored segment of each chromosome. Each PGT-M test design is unique and specific to the family, so DNA samples from both partners, and often additional family members, will be requested in order to design a test. Then, linkage analysis is used to determine the “genetic fingerprint” of the mutation and diagnose each tested embryo as affected or unaffected.

PGT-M Carrier

The PGT-M/SR Experience

CooperSurgical is the pioneer and worldwide leader of PGT-M/SR. Our team performed the first-ever PGT-M procedure, and has since performed more PGT-M/SR cases than all other labs combined. This level of experience allows us to confidently accept even the most complex cases, which are often turned down by other labs.

Genomics-Strip

The PGT-M Process

caseReview-gen

Case review

Ordering provider submits a TRF along with genetic testing reports for case review and approval.

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Genetic consultation

Registered patients speak with a genetic counselor
(PGT-M: discuss if additional genetic testing of the couple or other family members is required).

testPrep-gen

PGT-M process

PGT lab collects DNA samples from the couple and appropriate family members and designs a test unique to each family.

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IVF

In vitro fertilization is performed and the resulting embryos are incubated.

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Embryo biopsy

An embryologist carefully removes a small cell sample from each embryo.

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Vitrification

Embryos are frozen while awaiting PGT results.

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PGT-M

Biopsied samples are sent to the PGT laboratory, testing is performed, and results are released to the IVF center.

emb-trans-gen

Embryo transfer

If available, a chromosomally normal embryo is selected for transfer. Additional euploid embryos can remain frozen for future use.